September 2016 – Chicago Center for Functional Annotation

Brucella abortus ΔrpoE1 confers protective immunity against wild type challenge in a mouse model of brucellosis

The Brucella abortus general stress response (GSR) system regulates activity of the alternative sigma factor, σ(E1), which controls transcription of approximately 100 genes and is required for persistence in a BALB/c mouse chronic infection model. We evaluated the host response… Read more ›

Sep 01, 2016

Gyorgy Babnigg

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The Functional Genomics Program for understanding the functions of uncharacterized genes in infectious disease pathogens aims to generate experimental data to determine the biochemical function(s) of hypothetical genes, unknown open reading frames, and noncoding RNAs. The program applies state-of-the-art technologies to determine the biochemical and physiological roles of these gene components. Obtaining a more comprehensive understanding of uncharacterized genes in infectious disease pathogens will lead to improved genomic annotation and allow for the development of potential new targets for medical diagnostics, therapeutics and vaccines. Contact Information Dr. Alison Yao (link is external) Punam Mathur (link is external) Main Areas of Focus To obtain a more comprehensive understanding of uncharacterized genes in infectious disease pathogens To lead to improved genomic annotation and allow for the development of potential new targets for medical diagnostics, therapeutics and vaccines To distribute data, software, and reagents generated from research projects to the broader scientific community Functional Genomics Steering Committee The Functional Genomics Steering Committee is designed to review the progress in meeting the program’s goals and will make recommendations for the continuation or re-direction of all projects and activities on an ongoing basis and in consultation with the NIAID staff. The Steering Committee consists of investigators who are not current collaborators of the funded centers. Josh Adkins (link is external) – Pacific Northwest National Laboratory James Bliska (link is external) – Stony Brook University Victor DiRita (link is external) (Chair) – Michigan State University Jennifer Gardy (link is external) – BC Centre for Disease Control Michael Laub (link is external) – Massachusetts Institute of Technology Kathleen McDonough (link is external) – Wadsworth Center NYSDOH Jim Musser (link is external) – The Methodist Hospital David Pompliano (link is external) – Third Rock Ventures Roz Sandri-Goldin (link is external) – University of California Irvine Tom Slezak (link is external) – Lawrence Livermore National Laboratory Sri Sreevatsan (link is external) – University of Minnesota Renee Tsolis (link is external) – University of California Davis Dave Wentworth (link is external) (Vice-Chair) – CDC

Chicago Center for Functional Annotation

Monthly Archives: September 2016

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Brucella abortus ΔrpoE1 confers protective immunity against wild type challenge in a mouse model of brucellosis