Glutathionylation of Yersinia pestis LcrV and Its Effects on Plague Pathogenesis

The Schneewind lab identified the role of glutathionylation of Yersinia pestis LcrV, the cap protein of bacterial type III secretion needles. This modification contributes to the high virulence of Y. pestis in mouse and rat models for bubonic plague. Their finding als suggest that Y. pestis exploits glutathione in host tissues to activate a virulence strategy, thereby accelerating plague pathogenesis.


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