Host infection by microbial pathogens cues global changes in microbial and host cell biology that facilitate microbial replication and disease. The complete maps of thousands of bacterial and viral genomes have recently been defined; however, the rate at which physiological… Read more ›
Brucella abortus is an intracellular bacterial pathogen and an etiological agent of the zoonotic disease known as brucellosis. Brucellosis can be challenging to treat with conventional antibiotic therapies and, in some cases, may develop into a debilitating and life-threatening chronic… Read more ›
Brucella abortus ΔrpoE1 confers protective immunity against wild type challenge in a mouse model of brucellosis
The Brucella abortus general stress response (GSR) system regulates activity of the alternative sigma factor, σ(E1), which controls transcription of approximately 100 genes and is required for persistence in a BALB/c mouse chronic infection model. We evaluated the host response… Read more ›
WrpA is an atypical flavodoxin-family protein under regulatory control of the Brucella abortus general stress response system.
The general stress response (GSR) system of the intracellular pathogen Brucella abortus controls transcription of approximately 100 genes in response to a range of stress cues. The core genetic regulatory components of the GSR are required for B. abortus survival… Read more ›
Structural asymmetry in a conserved signaling system that regulates division, replication and virulence of an intracellular pathogen.
We have functionally and structurally defined an essential protein phosphorelay that regulates expression of genes required for growth, division, and intracellular survival of the global zoonotic pathogen Brucella abortus. Our study delineates phosphoryl transfer through this molecular pathway, which initiates… Read more ›
The 2016 NIAID Functional Genomics program meeting will be hosted by Harvard University on May 2-4, 2016 in Boston, MA.
YfbA, a Yersinia pestis regulator required for colonization and biofilm formation in the gut of cat fleas.
Tam, C., Demke, O., Hermanas, T., Mitchell, A., Hendrickx, A.P., and Schneewind, O. 2014. YfbA, a Yersinia pestis regulator required for colonization and biofilm formation in the gut of cat fleas. J. Bacteriol. doi: 10.1128/JB.01187-13.
The Crosson Lab has defined the B. abortus effector protein, RicA, as a carbonic anhydrase-like zinc metalloprotein. This work was published in Biochemistry.