The general stress response sigma factor σE1 directly and indirectly regulates the transcription of dozens of genes that influence stress survival and host infection in the zoonotic pathogen Brucella abortus. Characterizing the functions of σE1-regulated genes therefore would contribute to… Read more ›
The 2018 annual meeting will be held April 9-10 at the University of Chicago Gordon Center for Integrative Sciences. The meeting will feature several scientific sessions, including presentations from senior personnel and trainees. Functional Genomics Project personnel, Steering Committee members,… Read more ›
Gene network analysis identifies a central post-transcriptional regulator of cellular stress survival
The Crosson lab described a network-based approach to interrogate publicly available transcription data to predict genes that serve major functional roles in Caulobacter crescentus stress survival. This approach identified GsrN, a conserved small RNA whose expression is both necessary and… Read more ›
The Schneewind lab identified the role of glutathionylation of Yersinia pestis LcrV, the cap protein of bacterial type III secretion needles. This modification contributes to the high virulence of Y. pestis in mouse and rat models for bubonic plague. Their… Read more ›
Conserved ABC Transport System Regulated by the General Stress Response Pathways of Alpha- and Gammaproteobacteria
The Crosson lab defined the structure and function of a member of the conserved putative membrane transport system YehZYXW, whose expression is strongly activated by σE1 an EcfG family sigma factor that regulates the transcription of dozens of genes in… Read more ›
The 2017 Functional Genomics meeting will take place in Charleston, South Carolina on April 25-26.
A Functional Genomics publication describes the ways high-throughput functional genomics can lead to new therapeutics and better understanding of the next generation of emerging pathogens by rapidly defining new general mechanisms by which organisms cause disease and replicate in host… Read more ›
The 2016 NIAID Functional Genomics program meeting will be hosted by Harvard University on May 2-4, 2016 in Boston, MA.
The Crosson Lab has defined the B. abortus effector protein, RicA, as a carbonic anhydrase-like zinc metalloprotein. This work was published in Biochemistry.